Hui Zheng

Hui received his B.S. degree at Tsinghua University in 2005 where he did research investigating the maintenance of embryonic stem cell pluripotency. His focus was on the transcriptional regulation of Nanog, a gene essential for embryonic stem cell pluripotency.

Hui is now a graduate student in Department of Pharmacology with advisor, Dr. Ping-Yee Law. His research is investigating the agonist-selective signaling of G protein-coupled receptors using the opioid receptor as a model. The determinants, phenomena and consequences of agonist-selective signaling were illustrated during his study. In addition, he is exploring the mechanism of opioid tolerance development by exploring the gene regulations induced by opioids.

Awards and Honors:

• ASPET travel award to the 2008 Experimental Biology Meeting
• Academic Excellence Scholarship Award, Tsinghua University (2004)
• Academic Excellence Scholarship Award, Tsinghua University (2002)

Thesis Publications:

Zheng, H., Chu, J., Qiu, Y., Loh, H. H. & Law, P. Y. (2008) Agonist-selective signaling is determined by the receptor location within the membrane domains.Proc Natl Acad Sci U S A 105, 9421-6.

Chu, J., Zheng, H., Loh, H. H. & Law, P. Y. (2008) Morphine-induced mu-opioid receptor rapid desensitization is independent of receptor phosphorylation and beta-arrestins.Cell Signal 20, 1616-24.

Zeng, H., Loh, H. H. & Law, P. Y. (2008) ?-Arrestin-Dependent ?-Opioid Receptor-Activated Extracellular Signal-Regulated Kinases (ERKs) Translocate to Nucleus in Contrast to G Protein-Dependent ERK Activation.Mol Pharmacol 73, 178-90.