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Hon Man Hamlet Chu
Hamlet Chu received a B.S. degree in Biochemistry from the University of Wisconsin-Madison in 2004. He then joined the University of Minnesota MICaB program in 2005.
Since then Hamlet has been carrying out his thesis research in the laboratory of Dr. Marc Jenkins in the Department of Microbiology. His research focuses on the analysis of the polyclonal pre-immune T cell repertoire in mice and humans. The two main aims of his thesis project are:
1) Development of the novel peptide-MHCII tetramer enrichment method to detect antigen-specific pre-immune T cells, and characterization of their primary immune response 2) Investigating how a diverse yet antigen-specific polyclonal T cell repertoire is generated.
Awards and Honors:
- J. Jacob Kaplan Award, University of Minnesota (2009)
- Predoctoral Fellowship, American Heart Association, Midwest Affiliation (2008-2009)
- Travel Award, MICaB Graduate Program, University of Minnesota, Minneapolis, MN (2008)
- Scholarship, Keystone Symposia, Immunological Memory (2007); Tolerance in Transplantation and Autoimmunity
- Golden Pipetman Award, MICaB Graduate Program, University of Minnesota, Minneapolis, MN (2007)
Thesis Publications:
Chu HH, Moon JJ, Takada K, Pepper M, Molitor JA, Schacker TW, Hogquist KA, Jameson SC, Jenkins MK. 2009. Positive Selection optimizes the number and function of MHCII-restricted CD4+ T cell clones in naïve polyclonal repertoire. PNAS, in press.
Moon JJ, Chu HH, Hataye J, Pagán AJ, Pepper M, McLachlan JB, Zell T, and Jenkins MK (2009). Tracking antigen-specific T cells. Nat Protoc Apr:4(4): 565-581.
Burchill MA, Yang J, Kang KB, Moon JJ, Chu HH, Lio CW, Vegoe AL, Hsieh CS, Jenkins MK, Farrar MA. 2008. Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity Jan;28(1):112-21.
Moon JJ*,Chu HH*, Pepper M, McSorley SJ, Jameson SC, Kedl RM, Jenkins MK. 2007. Naïve CD4+ T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. Immunity Aug;27(2):203-13. (*co-first authors). (Preview by Mark M Davis: Immunity Preview)
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