Guylaine Hache

Guylaine Haché received her B.S. degree from Bemidji State University where she majored in Biology and Chemistry.

Guylaine is a graduate student in the Department of Biochemistry, Molecular Biology and Biophysics working in the laboratory of Dr. Reuben Harris. Guylaine's research focuses on understanding the mechanism by which human APOBEC3 proteins inhibit the replication of HIV. 

Awards and Honors:

• Young Investigator Award, Conference on Retroviruses and Opportunistic Infections, 2009 
• Student Travel Grant, American Society for Virology, 2008
• Doctoral Research Award, Canadian Institutes for Health Research, 2006-2009
• Postgraduate Research Award, Natural Sciences and Engineering Research Council of Canada, 2005-2006

Thesis Publications:

Guylaine Haché, and Reuben S. Harris. (2009) An Alternative to “APOBEC3G and APOBEC3F Require an Endogenous Cofactor to Block HIV-1 Replication”, submitted

Guylaine Haché, Truus E.M. Abbink, Ben Berkhout and Reuben S. Harris. (2009) Optimal Translation Initiation Enables Vif-deficient HIV-1 to Escape Restriction by APOBEC3G. Journal of Virology, In Press (doi:10.1128/JVI.00045-09)

Guylaine Haché, Keisuke Shindo, John S. Albin and Reuben S. Harris. (2008) Evolution of HIV-1 isolates that use a novel Vif-independent mechanism to resist restriction by human APOBEC3G. Current Biology, 18(11):819-24

April J. Schumacher, Guylaine Haché, Donna MacDuff, William L. Brown and Reuben S. Harris. (2008) The DNA Deaminase Activity of Human APOBEC3G is Required for Ty1, MusD, and HIV-1 Restriction. Journal of Virology, 82(6):2652-60

Guylaine Haché, Louis M. Mansky and Reuben S. Harris. (2006) Human APOBEC3 Proteins, Retrovirus Restriction and HIV Drug Resistance. AIDS Reviews, 8(3):148-57

Stefán R. Jónsson, Guylaine Haché, Mark D. Stenglein, Scott C. Fahrenkrug, Valgerdur Andrésdóttirand Reuben S. Harris. (2006) Evolutionarily conserved and non-conserved retrovirus restriction activities of artiodactyl APOBEC3F proteins. Nucleic Acids Research, 34(19):5683-94

Guylaine Haché, Mark T. Liddament and Reuben S. Harris. (2005) The Retroviral Hypermutation Specificity of APOBEC3F and APOBEC3G is Governed by the C-terminal DNA Cytosine Deaminase Domain. Journal of Biological Chemistry, 280(12):10920-4